Elastase



Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation. The images at the left and at the right correspond to one representative elastase structure, i.e. the human Matrix Metalloproteinase-12 (MMP12), which is macrophage ELA (3ba0). Calcium ions are shown as green balls, zinc ions are grey balls and acetohydroxamic acid is shown as space filling object.

3D structures of elastase
Update June 2011

MMP12
3lka - hMMP12 catalytic domain+hydroxamic acid+paramethoxy-sulfonyl amide – human

3ba0, 1jk3 – hMMP12

3ehx, 3ehy, 1utt, 1utz, 1ros - hMMP12 catalytic domain+inhibitor

2oxu - hMMP12 catalytic domain

2oxw, 2oxz - hMMP12 catalytic domain+peptide

2hu6 - hMMP12 catalytic domain+bicyclic inhibitor

1rmz - hMMP12 catalytic domain+ inhibitor NNGH

1y93 - hMMP12 catalytic domain+acetohydroxamic acid

1jiz – hMMP12+ hydroxamic acid

1os2 - hMMP12 (mutant)+hydroxamic acid

1os9 - hMMP12 (mutant)

3f15, 3f16, 3f17, 3f18, 3f19, 3f1a, 3n2u, 3n2v, 3nx7 - hMMP12 catalytic domain+sulfonamide inhibitor

2w0d - hMMP12 catalytic domain (mutant)

2krj, 2k9c – hMMP12 fraction – NMR

2jxy - hMMP12 hemopexin-like domain – NMR

2k2g - hMMP12 catalytic domain+inhibitor – NMR

2poj - hMMP12 catalytic domain – NMR

2z2d - hMMP12 catalytic domain+butanoic acid – NMR

1ycm, 1z3j – hMMP12 (mutant)+hydroxamic acid derivative - NMR

3lk8 - hMMP12 catalytic domain (mutant)+hydroxamic acid derivative

2wo8, 2wo9, 2woa – hMMP12 fraction+hydroxy carboxylic acid

3lik, 3lil, 3lir, 3ljg – hMMP12 catalytic domain (mutant)+chelating inhibitor

MMP16
1rm8 – hMMP16+batimastat

ELA
3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est, 2oqu, 3odd, 3odf – pELA1 – pig

3hgn – pELA1+peptidyl inhibitor – neutron

3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est, 6est - pELA1+peptidyl inhibitor

1fzz – pELA1+ONO-6818

1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor

1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam

1eai – pELA1+Ascaris inhibitor

2d26 – pELA1+α-1-antitrypsin

1fle – pELA1+elafin

1b0e, 1b0f – pELA1+MDL

2v35 – pELA1+JM54

2iot – pELA1+clavulanic acid

2de9 – pELA1+tris

1uvo, 1uvp, 1lka, 1lkb – pELA1+ions

1gwa – pELA1+I3

1uo6, 1c1m – pELA1+Xe

1l0z, 1l1g - pELA1+Xe+Br

2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7

2bda – pELA1+N-acetyl-NPI

1mcv – pELA1+squash inhibitor

1bma – pELA1+aminimide

1elf, 1elg – pELA1+peptidyl hydroxylamine

1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor

1esa, 1esb – pELA1 intermediate

1eas, 1eat, 1eau – pELA1+pyridine inhibitor

1inc – pELA1+benzoxazinone

1jim, 9est, 8est – pELA1+coumarin derivative

2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent

3dbk – PaELA+phophoramidon – Pseudomonas aeruginosa

1u4g – PaELA+HPI

1ezm - PaELA

1elt – ELA - salmon

ELA2
3q76 – hELA2

3q77 – hELA2+dihydropyrimidone inhibitor

2z7f – hELA2 peptidase domain +antileukoproteinase

2rg3 – hELA2+sulfonic inhibitor

1h1b, 1ppg, 1hne – hELA2+inhibitor

1ppf – hELA2+ovomucoid

1b0f – hELA2+MDL101146